The Science Behind Hormonic Base: 16 Nutrients

Hormonic Base is a physician-developed supplement for women who want to support their body daily with 16 micronutrients and bioactive compounds. The formula is based on scientific research regarding energy metabolism, the nervous system, cellular protection, and other fundamental bodily functions. In this article, we present the ingredients and the currently investigated research results.

Hormonic Base: Your daily support with selected micronutrients

Hormonic Base combines selected micronutrients in a well-thought-out formula. It is based on scientific research into fundamental bodily functions such as energy metabolism, hormonal processes, the nervous system, and the protection of cells from oxidative stress, for example via authorized nutrient functions of vitamin B6, magnesium, or vitamin E.*

Why do we combine 16 nutrients? Research suggests that nutrients take on complementary roles, for instance as co-factors in energy metabolism or within antioxidant networks, and can mutually enhance each other's effects. Likewise, formulation and matrix—such as carrier substances or the combination of several micronutrients—are considered possible influencing factors for bioavailability, i.e., the body's ability to absorb them. We have structured the formula to meaningfully supplement what the body needs daily: without unnecessary additives, with a focus on quality and transparency.

What motivates us? The creation of Hormonic Base was shaped by the personal experiences of our founders, Lee and Lisa, with women's health issues. From this perspective emerged the desire for a clear, evidence-based nutritional foundation for everyday life. It is important to us to draw a distinction: Hormonic Base is not a medicine, but a food supplement that can meaningfully supplement daily nutrient intake. You are welcome to book an appointment with our doctors at any time to discuss your personal situation.

Part of a modular system: Hormonic Base forms the core of our progressive supplement approach as a base supplement with essential active ingredients for women in every phase of life. For specific needs, it can be combined with our add-on formulas: the Cycle+ Formula for the cycle and ovulation, the Midlife Formula for menopause, and the Shape Formula for metabolism. We always recommend combining these with the Base.

The formula at a glance

This overview shows you all the active ingredients in Hormonic Base at a glance. The magnesium complex combines three forms: bisglycinate, malate, and citrate.

Active ingredient	Category	Studied for
Curcumin	Plant-based	Inflammation, blood sugar, oxidative stress
Coenzyme Q10	Vitamin-like substance	Mitochondria, insulin sensitivity
Vitamin D3	Vitamin	Cycle, immune system, bones
Vitamin K2	Vitamin	Bones, calcium distribution
Folate (B9)	Vitamin	Egg cell maturation, homocysteine
Vitamin B6	Vitamin	Hormonal activity, PMS, mood
Magnesium complex	Mineral (3 forms)	Sleep, blood sugar, period pain
Vitamin E	Antioxidant	Cell protection, bones, inflammation
Zinc	Trace element	Skin, insulin sensitivity, PMS
Chromium picolinate	Trace element	Blood sugar, body composition
Selenium	Trace element	Thyroid, cell protection
L-Glycine	Amino acid	Sleep quality, oxidative stress
NAC	Amino acid precursor	Glutathione, ovulation in PCOS
Capsaicin	Plant-based	Thermogenesis, appetite regulation

What is curcumin?

Curcumin is the active component of turmeric, a natural spice known for its anti-inflammatory and antioxidant properties. It has been used for centuries in traditional medicine and has recently gained attention due to its potential benefits for metabolism, immune protection, and hormonal balance, according to studies.

The research background

Curcumin is investigated in scientific studies in the context of reducing inflammation, oxidative stress, insulin sensitivity, and blood sugar regulation. These properties make curcumin interesting for women whose hormonal balance easily gets out of sync, for instance through silent inflammation, cycle changes, or a sensitive blood sugar balance.*

Insights from scientific studies

Significance in inflammation: In a randomized, controlled trial, curcumin led to a significant reduction in markers for systemic inflammation such as C-reactive protein (CRP) compared to a placebo (Panahi et al., 2015).
Blood sugar regulation: A meta-analysis involving 18 studies and 1,382 subjects reports that curcumin lowered fasting blood sugar by 11.48 mg/dL and HbA1c levels by 0.54 percentage points in a statistically significant manner (Mokgalaboni et al., 2024).
Role in oxidative stress: Studies report reduced MDA levels and increased antioxidant capacity; individual papers also examine PCOS-associated parameters and indicate that curcumin could potentially improve PCOS-associated hyperandrogenism and hyperglycemia (Heshmati et al., 2021; Tabrizi et al., 2019).

What is Coenzyme Q10?

Coenzyme Q10 (CoQ10) is a fat-soluble, vitamin-like substance found in the mitochondria of all cells. It plays a key role in energy production (ATP) in the mitochondria. CoQ10 levels decrease with advancing age and in chronic conditions such as PCOS, diabetes, and cardiovascular diseases, which can lead to an energy deficiency at the cellular level and increased oxidative stress.

The research background

Scientific research discusses the role of CoQ10 in mitochondrial function, the reduction of oxidative stress, and the framework of improved insulin sensitivity. Some studies also investigate the connection between CoQ10 and parameters such as egg cell quality, metabolic regulation, or energy levels, especially in the context of hormonal challenges.*

Insights from scientific studies

Role in insulin resistance: In a randomized, controlled trial, CoQ10 supplementation in participants with PCOS showed a significant improvement in HOMA-IR, indicating increased insulin sensitivity (Samimi et al., 2017).
Mitochondrial function: Pérez-Sánchez et al. report that CoQ10 supports mitochondrial function by increasing energy production and enhancing the antioxidant capacity of cells. This is discussed by the authors as particularly beneficial in metabolic and hormonal disorders (Pérez-Sánchez et al., 2017).
Oxidative stress markers: Izadi et al. found that CoQ10 lowered measured markers for oxidative stress and increased the antioxidant capacity of cells in study participants with PCOS (Izadi et al., 2019).

What is Vitamin D3?

Vitamin D3 (cholecalciferol) is a fat-soluble vitamin that the body produces itself upon exposure to sunlight. It is a prohormone involved in the regulation of calcium and phosphorus balance and the immune system. Authorized nutrient functions include, among others, the normal absorption and utilization of calcium and phosphorus, the maintenance of normal bones and muscles, as well as the normal function of the immune system.

The research background

Vitamin D3 plays an important role in many bodily processes. Studies indicate that it may also play a role in the context of inflammation regulation and hormonal processes, particularly relevant for women in sensitive life phases.*

Insights from scientific studies

Significance for the cycle: In a quantitative study with 545 women with PCOS, Wehr et al. describe connections between vitamin D status and cycle regularity as well as metabolic parameters (Wehr et al., 2011).
Influence on insulin sensitivity: Muscogiuri et al. report in their review paper that sufficient vitamin D intake may be associated with better insulin sensitivity and more stable blood sugar levels (Muscogiuri et al., 2017).
Connection with inflammation markers: The scientific statement of the Endocrine Society discusses the role of vitamin D in non-skeletal processes, including inflammation regulation and immune function (Rosen et al., 2012).

What is Vitamin K2?

Vitamin K2 is a fat-soluble vitamin that exists in two main forms: MK-4 and MK-7. It is crucial for calcium metabolism and activates proteins such as osteocalcin and matrix Gla protein, which direct calcium into the bones while simultaneously counteracting vascular calcification caused by excess calcium in the blood.

The research background

Vitamin K contributes to normal blood clotting and the maintenance of normal bones. Further scientific research indicates that vitamin K2, in combination with vitamin D3, can have positive effects on the function of certain calcium-regulating proteins. It is also being intensely researched in the context of vascular functions and calcium distribution in the body.*

Insights from scientific studies

Role in estrogen deficiency: Knapen et al. found that vitamin K2 significantly improved bone geometry and bone strength indices in study participants in menopause, a life phase typically characterized by estrogen deficiency (Knapen et al., 2007).
Role in vascular calcification: Beulens et al. reported that a high menaquinone intake in their cohort was associated with less coronary calcification (Beulens et al., 2009).
Bioavailability of MK-7: Schurgers et al. demonstrated that MK-7 from natto remains available in the blood longer compared to vitamin K1, thereby potentially allowing for a more stable supply (Schurgers et al., 2007).

What is Vitamin B9 (Folate)?

Vitamin B9, also known as folate (natural form) or folic acid (synthetic form), is a water-soluble vitamin that plays a role in DNA formation, cell division, and the production of red blood cells. It is also relevant to homocysteine metabolism, an important marker for cardiovascular and metabolic health.

Research background

Folate contributes to normal blood formation and cell growth during pregnancy. Studies have also found associations between folate, hormone parameters, and egg cell maturation, even in women with hormonal challenges such as PCOS or fertility issues.*

Insights from scientific studies

Egg cell maturation: Based on their study results, Gaskins et al. report that higher folate intake in women undergoing fertility treatment was associated with better reproductive outcomes (Gaskins et al., 2014).
Influence on homocysteine levels: Forges et al. describe that folate lowers elevated homocysteine levels in the blood. These levels are also discussed in the context of metabolic health in women with PCOS (Forges et al., 2007).
Importance in neural tube defects: In the classic study by Czeizel, sufficient folic acid intake around the time of conception significantly reduced the risk of neural tube defects (Czeizel, 1993).

What is Vitamin B6?

Vitamin B6, also called pyridoxine, is a water-soluble vitamin that exists in various forms in the body. It plays an essential role in amino acid metabolism, neurotransmitter synthesis, and the regulation of hormonal activity.

Research background

Vitamin B6 contributes to the regulation of hormonal activity, normal nervous system function, and the reduction of tiredness and fatigue.* Studies also research its influence on emotional well-being, neurotransmitter synthesis, and hormonal changes during the menstrual cycle.

Insights from scientific studies

Role in period pain: The randomized pilot study by Retallick-Brown et al. found that vitamin B6 alleviated premenstrual symptoms such as mood swings, irritability, and breast tenderness. The parameters were collected subjectively via questionnaire (Retallick-Brown et al., 2020).
Mood and stress management: In a randomized crossover study, Curtin and Johnston found that vitamin B6 reduced depressive symptoms in female students who were using hormonal contraception (Curtin et al., 2023).
Contribution to body composition: According to the randomized study by Novin et al., vitamin B6 in combination with amino acids can positively influence body composition during a calorie-reduced diet (Novin et al., 2018).

What is Magnesium?

Magnesium is an essential mineral involved in over 300 enzymatic processes in the body. It plays a key role in energy metabolism, muscle and nerve function, and blood sugar regulation. Hormonic Base uses a magnesium complex that combines the highly bioavailable forms of magnesium bisglycinate, citrate, and malate.

Research background

Magnesium contributes to normal muscle and nerve function, supports energy metabolism, and helps to reduce tiredness and fatigue.* Studies also investigate its influence on sleep quality, stress regulation, and emotional balance, particularly in the context of cycle-dependent changes.

Insights from scientific studies

Role in glucose tolerance: A placebo-controlled study by Guerrero-Romero et al. showed that magnesium significantly improved blood sugar status in individuals with prediabetes and low magnesium levels (Guerrero-Romero et al., 2015).
Role in period pain: In their study, Walker et al. found that magnesium intake alleviated premenstrual complaints such as water retention in the study participants (Walker et al., 1998).
Sleep quality: In a placebo-controlled study, Abbasi et al. observed that magnesium improved sleep duration and sleep efficiency, particularly in study participants with sleep disorders (Abbasi et al., 2012).

What is Vitamin E?

Vitamin E is a fat-soluble antioxidant that helps protect cells from oxidative stress.* It comprises a group of eight compounds, including tocopherols and tocotrienols, with alpha-tocopherol considered the most biologically active form.

Research background

Studies examine the role of vitamin E in relation to antioxidant processes, hormone-dependent tissues, and female fertility, particularly with regard to the uterine lining, bone health, and cycle-related changes. Current research focuses primarily on the inflammation-modulating effect.*

Insights from scientific studies

Bone health: In a randomized, placebo-controlled study, Vallibhakara et al. documented that vitamin E favorably influenced bone turnover markers in postmenopausal women with osteopenia (Vallibhakara et al., 2021).
Association with endometrial thickness: Hashemi et al. investigated vitamin E supplementation in women with implantation failure and reported effects on endometrial thickness. Important context: This paper was later retracted; the evidence here is limited accordingly (Hashemi et al., 2019).
Significance in inflammation: Mahjabeen et al. report that delta-tocotrienol lowered inflammatory markers such as TNF-alpha and IL-6 in a randomized study (Mahjabeen et al., 2021).

What is Zinc?

Zinc is an essential trace element that plays a key role in numerous biological processes, including cell division, protein synthesis, and immune function. It contributes to the maintenance of normal skin, hair, and nails.*

Research background

Among other things, zinc contributes to the maintenance of normal skin and to normal fertility and reproduction.* Furthermore, studies research zinc in connection with inflammatory processes, insulin sensitivity, and menstrual complaints in women.

Insights from scientific studies

Role in skin blemishes: A randomized, double-blind study by Bamford et al. investigated oral zinc sulfate for rosacea. However, this study showed no significant advantage over placebo; the body of evidence regarding zinc and skin issues is mixed overall (Bamford et al., 2012).
Role in insulin sensitivity: Nazem et al. report that zinc supplementation in overweight individuals improved markers of sugar metabolism and antioxidant capacity (Nazem et al., 2023).
Role in period pain: According to the randomized, controlled study by Ahmadi et al., zinc improved premenstrual complaints in female students, including both mood dips and physical symptoms (Ahmadi et al., 2023).

Hormonic Base: 16 micronutrients as a daily foundation

Physician-developed for women: with vitamin B6, which contributes to the regulation of hormonal activity, a magnesium complex of bisglycinate, malate, and citrate, as well as vitamin D3, zinc, and selenium. Strictly quality-tested in German laboratories, without unnecessary additives.

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What is chromium picolinate?

Chromium is an essential trace element involved in various metabolic processes, particularly in the metabolism of carbohydrates, fats, and proteins.* In the form of chromium picolinate, an organic compound with high bioavailability, chromium can be efficiently absorbed and utilized by the body.

The research background

Chromium contributes to normal macronutrient metabolism and the maintenance of normal blood glucose levels.* Furthermore, studies are investigating the connections between chromium status, eating behavior, and metabolic regulation.

Insights from scientific studies

Significance for blood sugar fluctuations: In a randomized, placebo-controlled study, the combined administration of chromium and vitamin D3 improved insulin resistance markers in type 2 diabetes (Imanparast et al., 2020).
Role in fat loss and muscle mass: A study of 154 adults who received 200 or 400 µg of chromium picolinate per day during a 10-week diet phase found a more favorable body composition with higher lean body mass (Kaats et al., 1998).
Possible modulation of food cravings: Based on their study of overweight patients during a formula diet, Bahadori et al. discuss potential effects of chromium on insulin sensitivity and body composition (Bahadori et al., 1997).

What is selenium?

Selenium is an essential trace element that performs diverse functions in the body as a component of selenoproteins. It contributes to the protection of cells from oxidative stress, the normal function of the immune system, and normal thyroid function.*

The research background

Selenium contributes to the normal function of the immune system, the maintenance of normal hair and nails, and normal thyroid function.* Scientific studies are also exploring the link between selenium levels, the antioxidant defense system, and hormone-dependent processes such as thyroid metabolism.

Insights from scientific studies

Gestational diabetes: Yigit and Sayar found a 2.7-fold increased risk of gestational diabetes in women with low selenium levels below 80 ng/ml (Yigit et al., 2024).
Significance for the thyroid: In an intervention study with older adults with a low selenium status, Alehagen et al. reported positive effects of selenium and CoQ10 supplementation on thyroid hormones and quality of life (Alehagen et al., 2024).
Potential influence on blood sugar levels: A systematic review with meta-analysis of randomized studies reports that selenium could improve fasting blood glucose and insulin resistance markers in women with PCOS (Zhao et al., 2023).

What is L-glycine?

L-glycine is a non-essential amino acid that performs diverse functions in the body. It is a component of many proteins and also acts as a neurotransmitter in the central nervous system. Among other things, glycine is involved in processes of cell regeneration and the body’s own detoxification.

The research background

Scientific studies are investigating the influence of glycine on oxidative stress, liver function, and neuronal activity, particularly in the context of sleep regulation and cell health. The role of glycine is also increasingly being researched in connection with hormonal changes.*

Insights from scientific studies

Significance for sleep quality: In their studies, Bannai et al. found that L-glycine improved subjective sleep quality and daytime fatigue in individuals with restricted sleep (Bannai et al., 2012).
Role in oxidative stress: In a preclinical model, Kumar et al. showed that glycine in combination with NAC (GlyNAC) reduced glutathione deficiency and oxidative stress as well as improved mitochondrial functions (Kumar et al., 2023).
Support for nerve function: In basic scientific research, Furuya et al. describe that glycine and L-serine serve as important trophic factors for certain nerve cells (Furuya et al., 2000).

What is NAC?

N-acetylcysteine (NAC) is a stable precursor of the amino acid cysteine and serves as a starting substance for the body to form glutathione, one of the most important endogenous antioxidants. It has long been researched in connection with cell protection, detoxification processes, and the regulation of oxidative stress.

The research background

Scientific investigations are looking into the potential benefits of NAC in the regulation of oxidative processes, hormone-dependent metabolic pathways, and reproductive parameters, especially in women with cycle-related or metabolic challenges.*

Insights from scientific studies

Ovulation rate: Rizk et al. reported that NAC as a supplement to clomiphene increased ovulation rates in women with clomiphene-resistant PCOS compared to placebo (Rizk et al., 2005).
Hyperinsulinemia: Based on their investigations, Fulghesu et al. discuss that NAC could improve insulin sensitivity in women with PCOS (Fulghesu et al., 2002).
Potential protection against muscle fatigue: Medved et al. documented that NAC increased the availability of cysteine and glutathione in the muscle and attenuated fatigue during long, intense training (Medved et al., 2004).

What is capsaicin?

Capsaicin is the natural, spicy compound from chili peppers that is primarily known for its thermogenic properties. In the body, it is associated with processes such as heat production, energy expenditure, and the activation of brown fat cells.

The research background

Scientific investigations are exploring the influence of capsaicin on thermogenesis, energy metabolism, and various metabolic markers. Its role in connection with appetite regulation and eating behavior is also being intensely discussed, particularly in the context of weight stability and energy balance.*

Insights from scientific studies

Significance for energy expenditure: Based on their study findings, Inoue et al. report that capsinoids increased energy expenditure and fat oxidation in individuals with a higher BMI (Inoue et al., 2007).
Appetite and satiety: Reinbach et al. reported that capsaicin favorably influenced appetite and satiety in their studies. These are subjectively collected parameters (Reinbach et al., 2009).
Significance for metabolism: In their review article, Panchal et al. summarize how capsaicin is studied in the context of metabolic syndrome, including via the activation of fat metabolism (Panchal et al., 2018).

*Note: The mentioned functions of individual micronutrients are based, where applicable, on authorized health claims according to EU Regulation No. 432/2012 as well as on scientific studies regarding the respective ingredients. Further described connections regarding physiological processes, hormonal sequences, metabolic pathways, or study results serve exclusively for general scientific information. They do not constitute a health claim about our products and do not replace individual medical advice. Our products are not medicinal products and are not intended to diagnose, treat, cure, or prevent any disease. Food supplements are not a substitute for a balanced, varied diet and a healthy lifestyle.

Do you want to know which nutrients are right for you?

In a free 15-minute video consultation, you can discuss your situation with one of our doctors: from your symptoms and relevant blood markers to which supplements actually make sense for you. No obligation, from the comfort of your home.

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Conclusion: Science as a Foundation

The Hormonic Base is our attempt to provide an honest answer to a simple question: Which micronutrients are truly meaningful for women in their everyday lives? The answer is in this article, ingredient by ingredient, study by study. Not as a promise of a cure, but as a transparent foundation upon which you can decide for yourself.

As the foundation of our modular system, the Base can be supplemented depending on your life stage, for example with the Cycle+ Formula in the Cycle Bundleor the Midlife Formula in the Midlife Bundle. And if you would like to know in general which supplements make sense for women, you can find an independent assessment in our guide Which supplements should women take daily?.

Frequently Asked Questions about the Hormonic Base

What does the Hormonic Base contain?

The Hormonic Base contains 16 micronutrients and bioactive compounds: curcumin, coenzyme Q10, vitamin D3, vitamin K2, folate (vitamin B9), vitamin B6, a magnesium complex consisting of bisglycinate, malate, and citrate, vitamin E, zinc, chromium picolinate, selenium, L-glycine, N-acetylcysteine (NAC), and capsaicin. You can find the complete composition and dosages on the product page.

Is the Hormonic Base a medicinal product?

No. Hormonic Base is a dietary supplement and not a medicinal product. It is not intended to diagnose, treat, or prevent any disease. The study content presented in this article is for scientific information purposes only. Please consult a doctor before taking it if you have any existing medical conditions, are pregnant or breastfeeding, or are taking medication.

Kann ich die Hormonic Base mit anderen Hormonic Produkten kombinieren?

Ja, genau dafür ist sie gedacht. Die Base bildet das Fundament unseres modularen Systems und lässt sich mit den Add-on-Formeln kombinieren: Cycle+ rund um Zyklus und Eisprung, Midlife für die Wechseljahre und Shape für den Stoffwechsel. In den Bundles gibt es die Kombinationen mit Preisvorteil.

Warum enthält die Hormonic Base einen Magnesium-Komplex aus drei Formen?

Weil verschiedene organische Magnesiumformen unterschiedliche Eigenschaften mitbringen: Bisglycinat gilt als besonders magenfreundlich, Citrat als gut löslich, Malat spielt eine Rolle im Energiestoffwechsel. Der Komplex kombiniert alle drei. Magnesium trägt unter anderem zur normalen Funktion von Muskeln und Nerven und zur Verringerung von Müdigkeit und Erschöpfung bei.

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About the Author

Lisa Maria Emmer

Founder · Physician · Hormonic

Lisa Maria Emmer is co-founder and medical director at Hormonic. She supports women with hormonal problems every day and specializes in cycle health, PCOS, and menopause.

Note: This article is based on current scientific studies, reviews, and meta-analyses and is for informational purposes only. It does not replace medical advice, diagnosis, or treatment. Dietary supplements are not a substitute for a balanced, varied diet and a healthy lifestyle.

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The Science Behind Hormonic Base

Hormonic Base: Your daily support with selected micronutrients

The formula at a glance

What is curcumin?

The research background

Insights from scientific studies

What is Coenzyme Q10?

The research background

Insights from scientific studies

What is Vitamin D3?

The research background

Insights from scientific studies

What is Vitamin K2?

The research background

Insights from scientific studies

What is Vitamin B9 (Folate)?

Research background

Insights from scientific studies

What is Vitamin B6?

Research background

Insights from scientific studies

What is Magnesium?

Research background

Insights from scientific studies

What is Vitamin E?

Research background

Insights from scientific studies

What is Zinc?

Research background

Insights from scientific studies

What is chromium picolinate?

The research background

Insights from scientific studies

What is selenium?

The research background

Insights from scientific studies

What is L-glycine?

The research background

Insights from scientific studies

What is NAC?

The research background

Insights from scientific studies

What is capsaicin?

The research background

Insights from scientific studies

Conclusion: Science as a Foundation

Frequently Asked Questions about the Hormonic Base

Scientific Sources

About the Author

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